Tangled tau: Active pathology or footprint of disease?
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چکیده
منابع مشابه
Tangled tau: Active pathology or footprint of disease?
Alzheimer’s disease (AD) research is approaching crisis point. While disease prevalence relentlessly increases as the population ages, treatments are still limited in number and effect. There is little hope on the horizon as clinical trials for new AD drugs have a dishearteningly high failure rate– greater than any other field at 99.6% [1]. Most of the work on AD has focussed on beta-amyloid, w...
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Parkinson's disease (PD) represents a major challenge for health care systems around the world: it is the most common degenerative movement disorder of old age, affecting over 100,000 people in the UK alone (Schrag et al., 2000). Despite the remarkable success of treatments directed at potentiating or replacing dopamine within the brain, which can relieve symptoms for over a decade, PD remains ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia: Translational Research & Clinical Interventions
سال: 2017
ISSN: 2352-8737
DOI: 10.1016/j.trci.2017.10.007